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If one of these cells meets a foreign body, it will integrate parts from it – called – onto its own cell surface and present these to other immune cells: the T-cells.
This, however, could not be proved for the other molecules.” During a project (RGP0033/2015) coordinated by Meyer-Hermann and funded by the Human Frontier Science Program (HFSP), the BRICS researchers used data from laboratory experiments carried out by cooperation partners of the University of Oxford (Great Britain) in the laboratory of Michael L.
Dustin to simulate the formation of synapses using computer models.
“The decision whether the T-cell is activated or not depends on the number and affinity of antigen molecules recognised.
The formation of a completely structured synapse at the contact surface influences this activation”, says Anastasios Siokis, researcher of the HZI department “Systems Immunology” of Prof. Where immunological synapses are correctly formed, the It is not yet fully understood how the different molecules reach their place in the synapse.